SECTION II - EXERCISE PHYSIOLOGY AND SPORTS MEDICINE / RESEARCH PAPER
Impact of the TTN C > T Polymorphism on Selected Variables
of Aerobic and Anaerobic Capacity
after a 12-Week Training Program
1
Faculty of Physical Education, Gdansk University of Physical Education and Sport, Gdansk, Poland.
2
Faculty of Physical Education, Jozef Pilsudski University of Physical Education in Warsaw, Warsaw, Poland.
3
Department of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
4
Institute of Physical Culture Sciences, University of Szczecin, Szczecin, Poland.
Submission date: 2024-04-24
Final revision date: 2024-06-28
Acceptance date: 2024-07-31
Online publication date: 2024-09-26
Corresponding author
Agata Leońska-Duniec
Faculty of Physical Education, Gdansk University of Physical Education and Sport, Poland
Faculty of Physical Education, Gdansk University of Physical Education and Sport, Poland
KEYWORDS
TOPICS
ABSTRACT
The TTN gene encodes a large muscle protein called titin, which provides structure, stability, and flexibility to skeletal and cardiac sarcomeres. The aim of this study was to determine whether the TTN C > T polymorphism (rs10497520) influenced training-induced changes in selected variables of aerobic and anaerobic capacity. We studied genotypes distribution in a group of 156 Caucasian females examined for aerobic capacity evaluated by maximal oxygen uptake (VO2max), and anaerobic capacity measured with the Wingate anaerobic test, before and after a 12-week training program. The most important finding was a genotype by training interaction for anaerobic capacity (AnC) during the Wingate test (p = 0.003). In response to training, carriers of the CT and TT genotypes demonstrated a significant increase in the total amount of work accomplished. We also showed that the applied training program improved all the Wingate test variables in the CT + TT genotype group by 10%. The obtained results suggest that the CT and TT genotypes may enhance anaerobic power and anaerobic capacity changes induced by regular training. We also suggest that T allele carriers may possess a metabolic adaptive advantage towards the anaerobic metabolism. Thus, the TTN gene may be considered a promising marker used in sports science, underlying variability in achieving sporting goals in events where the anaerobic energy system predominates.
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