SECTION II - EXERCISE PHYSIOLOGY AND SPORTS MEDICINE / RESEARCH PAPER
Genotypic and Allelic Frequencies of the ACE I/D Polymorphism in Elite Moroccan Athletes and Controls: A Pilot Study
1
Department of Biology, Laboratory of Biology and Health, Ibn Tofail University, Kenitra, Morocco.
2
Sport Sciences Research Centre,, Rey Juan Carlos University, Fuenlabrada, Spain, Spain
3
Faculty of Medicine of Tunis, University Al Manar, Tunis, Tunisia.
4
International Institute of Sport Sciences (2I2S), Rennes, France.
5
Mohammed VI Center for Research & Innovation, Rabat, Morocco.
6
Laboratory of Ecology, Environment and Health, Human Health and Environment Team, Faculty of Sciences of Moulay Ismail University, Meknes, Morocco.
7
Department of Anesthesiology, Pharmacology, and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Submission date: 2024-02-20
Final revision date: 2024-04-19
Acceptance date: 2026-02-12
Online publication date: 2026-06-01
Corresponding author
Hassane Zouhal
Department of Sport Sciences and Physical Education, Sport Sciences and Physical Education Department, UFR APS - Université Rennes 2, France, France
Department of Sport Sciences and Physical Education, Sport Sciences and Physical Education Department, UFR APS - Université Rennes 2, France, France
KEYWORDS
TOPICS
ABSTRACT
This study sought to investigate the genotypic and allelic frequencies of ACE I/D polymorphisms in elite Moroccan road cyclists and field hockey players. Forty-three Moroccan elite male athletes (19 cyclists; 24 field hockey players) and 28 healthy non-athletes were recruited for the study. All participants underwent ACE I/D polymorphism genotyping by the polymerase chain reaction (PCR) using genomic DNA from blood samples. The genotypic distribution of the ACE I/D polymorphism was similar in elite athletes (DD: 46.50, ID: 44.20, II: 9.30%) and controls (DD: 42.90, ID: 46.40, II: 10.70%; X2 = 0.103, p = 0.949). The allelic distribution was also similar in elite athletes (D allele; 68.60, I allele: 31.40%) and controls (D allele; 66.07, I allele: 33.93%; X2 = 0.099, p = 0.752) as well as cyclists (D allele; 63.16, I allele: 36.84%) and field hockey players (D allele; 72.92, I allele: 27.08%; X2 = 0.937, p = 0.332). These novel data indicate no significant differences in the genotypic and allelic frequencies of the ACE I/D polymorphism between athletes and controls or between elite road cyclists and field hockey players of Moroccan origin.
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